Accessibility Tools

2023-10-02
Research highlights

How soluble misfolded proteins bypass chaperones at the molecular level

Nat. Commun. 2023, 14 (1), 3689

Meta-analysis of protein refolding studies and representations of GroEL, DnaK, HtpG, and client proteins
Subpopulations of soluble, misfolded proteins can bypass chaperones within cells. The extent of this phenomenon and how it happens at the molecular level are unknown.
Through a meta-analysis of the experimental literature we find that in all quantitative protein refolding studies there is always a subpopulation of soluble but misfolded protein that does not fold in the presence of one or more chaperones, and can take days or longer to do so. Thus, some misfolded subpopulations commonly bypass chaperones. Using multi-scale simulation models we observe that the misfolded structures that bypass various chaperones can do so because their structures are highly native like, leading to a situation where chaperones do not distinguish between the folded and near-native-misfolded states. More broadly, these results provide a mechanism by which long-time scale changes in protein structure and function can persist in cells because some misfolded states can bypass components of the proteostasis machinery.

Publications

Ritaban Halder, Daniel A. Nissley, Ian Sitarik, Yang Jiang, Yiyun Rao, Quyen V. Vu, Mai Suan Li, Justin Pritchard & Edward P. O’Brien

Contact with IF PAN scientists

This email address is being protected from spambots. You need JavaScript enabled to view it.
This email address is being protected from spambots. You need JavaScript enabled to view it.



See more

Laser cooling of atoms containing antimatter

Phys. Rev. Lett. 132, 083402

The cloud of exotic atoms made up of matter and antimatter was cooled by more than 200 degrees in a controlled manner. The international team of scientists from the AEgIS experiment working at CERN has made the first experimental demonstration of laser cooling of positronium atoms. This is anothe...

Temperature dependence of chromatic dispersion for hygroscopic liquids

Using a modified Abbe refractometer, the chromatic dispersion and temperature dependence of the refractive index of a range of hygroscopic liquids was measured from 390 to 1070 nm for temperatures from 1 to 45°C. To obtain an analytical formula, the Sellmeier formula was fitted to the experimenta...

Topological phase diagram of Eu-based compounds

Combined experimental, theoretical, and computational investigations have identified the origin of outstanding magnetooptical and magnetotransport properties of EuCd2As2 and provided topological and magnetic phase diagrams for various classes of Eu-based compounds.  
Save
Cookies user preferences
We use cookies to ensure you to get the best experience on our website. If you decline the use of cookies, this website may not function as expected.
Accept all
Decline all
Read more
Essential
Essential cookies
These cookies are necessary for the correct operation of the website and therefore cannot be disabled on this level; the use of these cookies does not involve the processing of personal data. While you can disable them via your browser settings, doing so may prevent the website from working normally.
Accept
Analytical cookies
These cookies are particularly intended to enable the website administrator to monitor the website traffic statistics, as well as the sources of traffic. Such data is typically collected anonymously.
Google Analytics
Accept
Decline