I will discuss the transformative potential of artificial intelligence (AI) in shaping the future of healthcare by 2035. Over the next decade, AI is set to influence every aspect of healthcare delivery, from diagnostics and treatment to patient care and operational efficiency. By harnessing advancements in machine learning, data analytics, and automation, healthcare systems have the opportunity to become more predictive, personalized, preventive, and participatory. Additionally, I will highlight key initiatives and pioneering efforts from my team at Massachusetts General Hospital and Harvard Medical School, showcasing how we are driving innovation at the forefront of this transformation.